|N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-b]噻唑-6-基)苯基)喹喔啉-2-甲酰胺x盐酸盐|CsnPharm

CAS No.: 1001645-58-4

N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide xhydrochloride Catalog No. CSN24314

Synonyms: CAY10559;SIRT 1933;SRT-1720 hydrochloride

SRT1720 2HCl is a selective SIRT1 activator.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. SRT 1720 is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). In diet-induced obese and diabetic leptin-deficient ob/ob mice, oral administration of 100 mg/kg SRT1720 once daily improves insulin sensitivity, lowers plasma glucose and increases mitochondrial capacity after one week of treatment^[1]. SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300^[2].
参考文献

[1] Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450(7170):712-716.
[2] Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R. Are sirtuins viable targets for improving healthspan and lifespan?. Nat Rev Drug Discov. 2012;11(6):443-461.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9762 mL
- 9.8810 mL
- 19.7620 mL
- 5 mM
- 0.3952 mL
- 1.9762 mL
- 3.9524 mL
- 10 mM
- 0.1976 mL
- 0.9881 mL
- 1.9762 mL

技术信息

CAS号

1001645-58-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H24ClN7OS

运输

蓝冰

分子量

506.02

别名

CAY10559;SIRT 1933;SRT-1720 hydrochloride;SRT-1720

溶解度

DMSO	38.0 mg/mL (75.1 mM)
Water	Insoluble
Ethanol	Insoluble

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N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide xhydrochloride Catalog No. CSN24314

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